Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 70638530, compound

HRID 596340Notes

Reaction equation

HRID 596340 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[C:4]=1[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:6].Br[C:30]([CH3:37])([CH3:36])[C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH3:36][C:30]([O:22][C:19]1[CH:20]=[CH:21][C:16]([C:13]2[CH:12]=[CH:11][C:10]([CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]3[C:23]([O:27][CH3:28])=[CH:24][CH:25]=[CH:26][C:3]=3[O:2][CH3:1])=[CH:15][CH:14]=2)=[CH:17][CH:18]=1)([CH3:37])[C:31]([O:33][CH2:34][CH3:35])=[O:32]

Participants

3

Reactant 2

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 21451929HCID 21451929, compound

Product 1

HCID 70638530HCID 70638530, compoundYield 20%

Procedure

Ethyl 2-methyl-2-{4-[2-(2,6-dimethoxy-benzamido)-ethyl]-biphenyl-4'-oxy]-propionate was prepared from 4-[2-(2,6-dimethoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl and ethyl 2-bromo-2-methyl-propionate analogous to Example 31. Yield: 20% of theory; m.p. < 20° C.

Sources & evidence

ORD record
ord-5ac8f4c756d94603b7ee96961941f490
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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