2-Bromo-2-methylpropanoic acid → HCID 21418533, compound

HRID 596342Notes

Reaction equation

HRID 596342 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=1[C:5]([NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:6].Br[C:28]([CH3:33])([CH3:32])[C:29]([OH:31])=[O:30]>C(Cl)(Cl)Cl.CO>[CH3:32][C:28]([O:22][C:19]1[CH:20]=[CH:21][C:16]([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]3[CH:23]=[CH:24][CH:25]=[CH:26][C:3]=3[O:2][CH3:1])=[CH:11][CH:12]=2)=[CH:17][CH:18]=1)([CH3:33])[C:29]([OH:31])=[O:30]

Participants

4

Reactant 2

HCID 749242-Bromo-2-methylpropanoic acidHCID 21451950HCID 21451950, compound

Product 1

HCID 21418533HCID 21418533, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

0.5 gm (1.4 millimols) of 4-[2-(2-methoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl were heated at 90°-130° C for 90 minutes with 0.025 gm of 2-bromo-2-methyl-propionic acid. The reaction product was isolated by chromatography on silicagel with chloroform/methanol (9:1) as the eluant. M.P. 133° C. M + H = 433;

Sources & evidence

ORD record
ord-4b096a48328a48178afb35da6113310e
Source dataset
uspto-grants-1977_03
Patent number
US04010279

Reaction notes

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