HRID596353

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID350536

2-Hydroxyacetohydrazide

C2H6N2O2

结构：O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1F)=NCC(=S)N2

HCID12371434

未命名化合物

PRODUCTS

生成物

结构：O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(CO)n1-2

HCID21450833

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

In the manner given in Preparation 1, a solution of 1,3-dihydro-7-nitro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione in n-butyl alcohol is heated to reflux with hydroxyacetic acid hydrazide to give 8-nitro-1-(hydroxymethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 4 8-(Trifluoromethyl)-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

WORKUP

后处理

customIn the manner given in Preparation 1