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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 596355Generated: October 28, 2026

2-Hydroxyacetohydrazide → 1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/596355

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-HydroxyacetohydrazideHCID 350536—
Reactant1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thioneHCID 12522154—
Solvent1-ButanolHCID 263—
Product1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 12522155—

Reaction Steps

In the manner given in Preparation 1, a solution of 1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione and hydroxyacetic acid hydrazide in n-butyl alcohol is refluxed to give 1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 6 8-Fluoro-1-(hydroxymethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04010177
Source datasetuspto-grants-1977_03
ORD IDord-6480a3197144444b9bb8977101beb582
Source noteuspto-grants-1977_03