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HRID596358

反应详情

EQUATION

反应方程式

HRID 596358 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)CBr
HCID89602

Bromoacetyl chloride

C2H2BrClO

结构：CC(=O)[O-].[Na+]
HCID517045

Sodium Acetate

C2H3NaO2

结构：NNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=NC1
HCID12390874

7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine

C15H13ClN4

PRODUCTS

生成物

1
结构：Clc1ccc2c(c1)C(c1ccccc1)=NCc1nnc(CBr)n1-2
HCID20205220

1-(Bromomethyl)-8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

C17H12BrClN4

PROCEDURE

实验过程

In the manner given in Preparation 10, 7-chloro-5-phenyl-3H-1,4-benzodiazepine-2-yl hydrazine is reacted with bromoacetyl chloride and after 1.5 hours with sodium acetate, then refluxed to give 8-chloro-1-(bromomethyl)6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 12 8-Fluoro-1-(Chloromethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

WORKUP

后处理

  1. temperaturerefluxed