HCID 20291841, compound → HCID 21450936, compound

HRID 596372Notes

Reaction equation

HRID 596372 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[CH2:24]([NH:26][CH2:27][CH:28]1[CH2:30][CH2:29]1)[CH3:25]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][N:26]([CH2:27][CH:28]4[CH2:30][CH2:29]4)[CH2:24][CH3:25])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

Participants

3

Reactant 2

HCID 20291841HCID 20291841, compoundHCID 20341223N-(Cyclopropylmethyl)ethanamine

Product 1

HCID 21450936HCID 21450936, compound

Procedure

In the manner given in Preparation 29, 8-bromo-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is treated with ethyl(cyclopropylmethyl)amine to give 8-bromo-1-[[(cyclopropylmethyl)ethylamino]methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 32 8-(Trifluoromethyl)-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-91fbcc2b7f584bf1bf24df4d38dac023
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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