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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 596373Generated: October 25, 2026

(Cyclopropylmethyl)methylamine → 8-(trifluoromethyl)-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/596373

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Cyclopropylmethyl)methylamineHCID 12919209—
Reactant8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21330780—
Product8-(trifluoromethyl)-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 21450880—

Reaction Steps

In the manner given in Preparation 29, 8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is treated with methyl(cyclopropylmethyl)amine to give 8-(trifluoromethyl)-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 33 8-Chloro-1-[[(cyclopropylmethyl)propylamino]methyl]-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04010177
Source datasetuspto-grants-1977_03
ORD IDord-dce1b98224864322a50d13cf6b84cb0a
Source noteuspto-grants-1977_03