N-(Cyclopropylmethyl)ethanamine → HCID 21450827, compound

HRID 596376Notes

Reaction equation

HRID 596376 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:6]=2[CH:24]=1.[CH2:25]([NH:27][CH2:28][CH:29]1[CH2:31][CH2:30]1)[CH3:26]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][N:27]([CH2:28][CH:29]4[CH2:31][CH2:30]4)[CH2:25][CH3:26])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:6]=2[CH:24]=1

Participants

3

Reactant 2

HCID 20341223N-(Cyclopropylmethyl)ethanamineHCID 21437280HCID 21437280, compound

Product 1

HCID 21450827HCID 21450827, compound

Procedure

In the manner given in Preparation 29, 8-fluoro-1-(chloromethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is treated with ethyl(cyclopropylmethyl)amine to give 8-fluoro-1-[[(cyclopropylmethyl)ethylamino]methyl]-6-(o-fluorophenyl)-4-H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 36 9-(Trifluoromethyl)-1-[[(cyclopropylmethyl)methylamino]methyl]-6-phenyl-4-H-s-triazolo[4,3-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-b84f951ee68c41b1a3ccf43898186530
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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