HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 8-Methoxypsoralen
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Edukt | HCID 118376979 | HCID 118376979 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Sulfuric Acid | HCID 1118 | — |
| Produkt | 8-Methoxypsoralen | HCID 4114 | 80% |
Reaktionsschritte
1.5 g of 6-(2′-chloroacetyl)-7-hydroxy-8-methoxycoumarin (0.006 mole) is cyclized by heating in 20 ml of acetone in the presence of 0.5 g sodium carbonate (0.007 mole), reducing using 1.4 mg of sodium borohydride (0.03 mole) and neutralizing in sulfuric acid medium. After vacuum filtration and evaporation and trituration in ethanol, 8-MOP is obtained (yield 80%). Lastly, the 8-MOP is recrystallized in ethanol.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09440940B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-283c87b7a0854014a44f533f237ffa58 |
| Quellennotiz | uspto-grants-2016_09 |