Formaldehyde → Benzophenone

HRID 596395Notes

Reaction equation

HRID 596395 reaction equation
[C:1]1([C:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3N3C=NN=C3CN=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=[O:22]>C(O)=O>[C:7]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:12]=1)(=[O:22])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 125625186-phenyl-4H-s-triazolo[4,3-a][1,4-]benzodiazepine

Product 1

HCID 3102Benzophenone

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In the manner given in Example 1, 8-chloro-1-[[ (2-propynyl)amino]3-[-6-phenyl-4H-s-triazolo[4,3-a][1,4-]benzodiazepine is heated in formic acid with aqueous formaldehyde to give 5-chloro-2-[3[(2-propynyl)methylamino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-66eaf92fcc644df7b3865447145d3ed9
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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