Formaldehyde → Benzophenone

HRID 596396Notes

Reaction equation

HRID 596396 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2N3C(CNCC#C)=NN=C3CN=[C:7]([C:20]3[C:25](F)=[CH:24][CH:23]=[CH:22][C:21]=3F)[C:6]=2[CH:28]=1.C=[O:30]>C(O)=O>[C:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:30])[C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][CH:28]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 21450905HCID 21450905, compound

Product 1

HCID 3102Benzophenone

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In the manner given in Example 1, 8-chloro-1-[[(2propynyl)amino]methyl]-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated in formic acid with aqueous formaldehyde to give 5-chloro-2',6'-difluoro-2-[3-[[(2propynyl)methylamino]methyl]-5-(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-938eb8bf928443b8b2e1c400dc2984fe
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

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