Methanesulfonyl chloride → HCID 21450897, compound

HRID 596401Notes

Reaction equation

HRID 596401 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25]O)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].CS(Cl)(=O)=O.[CH:32]1([CH2:35][NH2:36])[CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25][NH:36][CH2:35][CH:32]2[CH2:34][CH2:33]2)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

4

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 75646CyclopropanemethanamineHCID 21450879[5-Chloro-2-[3-[(dimethylamino)methyl]-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]phenyl]phenylmethanone

Product 1

HCID 21450897HCID 21450897, compound

Procedure

In the manner given in Example 47, 5-chloro-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4- yl]benzophenone is treated first with methanesulfonyl chloride followed by (cyclopropylmethyl)amine to give 5-chloro-2-[3-[[(cyclopropylmethyl)amino]methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record
ord-c2696641e1314644bcd2b0964092ab6f
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Reaction notes

Loading…