Methanesulfonyl chloride → HCID 21450941, compound

HRID 596406Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25]O)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].CS(Cl)(=O)=O.[CH:32]1([CH2:35][NH2:36])[CH2:34][CH2:33]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]([CH3:24])[CH3:23])=[N:19][N:18]=[C:17]2[CH2:25][NH:36][CH2:35][CH:32]2[CH2:34][CH2:33]2)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

Reactant 3

HCID 31297Methanesulfonyl chloride

HCID 75646Cyclopropanemethanamine

HCID 21450853HCID 21450853, compound

Product 1

HCID 21450941HCID 21450941, compound

Procedure

In the manner given in Example 47, 5-bromo-2-[3-(hydroxymethyl)-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone is treated first with methanesulfonyl chloride followed by (cyclopropylmethyl)-amine to give 5-bromo-2-[3-[[(cyclopropylmethyl)amino]-methyl]-5-[(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]-benzophenone.

Sources & evidence

ORD record: ord-c974d2914ed844bfa48fcf5bc683a3f4
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04010177

Reaction notes

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