反应详情

A cold solution of 1.60 g. (0.016 mole) of 4-aminothiazole in 20 ml. of dry pyridine is treated with 4.0 g. (0.017 mole) of acetylsulfanilyl chloride in small portions over 15 minutes. The reaction is allowed to warm slowly to room temperature and stirring continued for about 2 days. The red solution is diluted slowly with 120 ml. of water and then cooled in an ice-bath for 11/2 hours. The crystalline precipitate is collected and washed with a small amount of cold dilute hydrochloric acid followed by several portions of water. The yield of the air-dried cream-colored product is 4.10 g. (86%) m.p. 231°-2° C.

1. additionThe red solution is diluted slowly with 120 ml
2. customThe crystalline precipitate is collected
3. washwashed with a small amount of cold dilute hydrochloric acid