Acetic Anhydride → 3-(p-Acetylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole

Participants

Role	Name	HCID	Charge
Reactant	Acetic Anhydride	HCID 7918	—
Reactant	4-[5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl]aniline	HCID 20285812	—
Product	3-(p-Acetylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole	HCID 20285794	—

Reaction Steps

To 3-(p-aminophenyl)-5-(4-pyridyl)-1,2,4-triazole (1 g.) is added acetic anhydride (20 ml.) and the resulting suspension is heated 18 hours on a steam bath. The excess acetic anhydride is removed under reduced pressure and water (25 ml.) is added to the residue. After stirring 0.5 hour, the solid is filtered and recrystallized to yield 3-(p-acetylaminophenyl)-5-(4-pyridyl)-1,2,4-triazole.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04011218
Source dataset	uspto-grants-1977_03
ORD ID	ord-5ec2c873e2474ec9845f76c28f5434d6
Source note	uspto-grants-1977_03