HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Calcium Chloride | HCID 5284359 | — |
| Reactant | 8-fluoro-2-methyl-dibenzo[b,f]thiepin-10(11H)-one | HCID 12275541 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 10-Chloro-8-fluoro-10,11-dihydro-2-methyldibenzo[b,f]thiepin | HCID 12275543 | — |
Reaction Steps
103 G. of 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-one, 500 ml. of benzene and 38.4 g. of finely pulverized calcium chloride are saturated with hydrochloric acid gas at 15° and stirred overnight. The residue is filtered, washed with benzene and evaporated under reduced pressure, whereby there is obtained 10-chloro-8-fluoro-10,11dihydro-2-methyl-dibenzo[b,f]-thiepin, having a melting point of 63°-64°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04011222 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-37c1867bccdb488c8d180158a1f1d923 |
| Source note | uspto-grants-1977_03 |