Methyl isothiocyanate → 8-Methylthiocarbamoylamino-3-methyl-5,6,7,8-tetrahydroquinoline

Participants

Reaction Steps

The 8-amino product of Example 3 (free base) (3 g) was dissolved in acetonitrile (30 ml.) and the solution treated with methylisothiocyanate (1.35 g.) and heated at reflux for 2 hours. The solvent was removed in vacuo and the residual solid recrystallised from absolute ethanol to give the title compound as colourless needles (3 g.) m.p. 113° C.

Provenance & Evidence