HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isothiocyanate → 8-Benzoylthiocarbamoylamino-3-methyl-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isothiocyanate | HCID 68284 | — |
| Reactant | 3-Methyl-5,6,7,8-tetrahydroquinolin-8-amine | HCID 12358220 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-Benzoylthiocarbamoylamino-3-methyl-5,6,7,8-tetrahydroquinoline | HCID 12358245 | 60.2% |
Reaction Steps
A solution of 8-amino-3-methyl-5,6,7,8-tetrahydroquinoline (6 g.) in acetone (48 ml.) was treated with benzoylisothiocyanate (6 g.) and the mixture heated at reflux for 45 minutes. The solvent was removed in vacuo and the residual solid recrystallised from ethanol-ether to give the title compound as colourless needles (7.2 g.) m.p. 168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04011229 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-5da23d86839e4bc9be3bd51fe207d3fb |
| Source note | uspto-grants-1977_03 |