反应详情

温度

10 °C

β-Nitrostyrene (7.5 grams, 0.050 mole) was added to a cooled (10° C.) stirred slurry of ammonium 1-pyrrolidinecarbodithioate (8.2 grams, 0.050 mole) in methanol (50 ml.). The temperature of the mixture fell to 5° C., then rapidly climbed to 10° C. The cooling bath was removed and the reaction temperature rose slowly to 22° C. Acetic acid (3.0 grams, 0.05 mole) was added, the slurry was cooled to 10° C. and the solid was filtered off, washed with water, and dried in air. The crude product melted at 108° C.-116° C. and weighed 11.4 grams (77% yield). Repeated recrystallizations from cool acetone-methanol, hot acetone-2-propanol, and cool methylene chloride-toluene-hexane solutions gave pure α-(nitromethyl)benzyl 1-pyrrolidinecarbodithioate melting at 116° C.-120° C. (sintering at 113° C.).

1. customfell to 5° C.
2. customrapidly climbed to 10° C
3. customThe cooling bath was removed
4. customrose slowly to 22° C
5. temperaturethe slurry was cooled to 10° C.
6. filtrationthe solid was filtered off
7. washwashed with water
8. customdried in air
9. customrecrystallizations
10. temperaturefrom cool acetone-methanol, hot acetone-2-propanol
11. temperaturecool methylene chloride-toluene-hexane solutions