HCID 896334, compound → HCID 21449927, compound

Participants

Reaction Steps

Substitution of an equivalent amount of other heterocyclic acid chlorides, e.g., pyridine 2-, 3-, and 4-carboxylic acid chlorides; thenoyl 2- and 3-chlorides, coumariloyl chloride for thiazole-4-carboxylic acid chloride provides a convenient synthesis for: 2-(pyridine-2-carboxamido)benzimidazole, 2-(pyridine-3-carboxamido)benzimidazole, 2-(pyridine-4-carboxamido)benzimidazole, 2-(thiophene-2-carboxamido)benzimidazole, 2-(coumariloyl)aminobenzimidazole, m.p. 293°- 295° C. λmax. 327 mμ, E11%cm. 1024 and 2-nicotinamidoaminobenzimidazole, λmax. 319 mμ, E1cm.1% 429.

Provenance & Evidence