Benzoyl chloride → HCID 178423990, compound

Participants

Reaction Steps

Cyanamide (3.44 g.) is dissolved in 69 ml. of pyridine and the mixture is held at 0°-4° C. While stirring, benzoyl chloride (11.5 g.) is added in portions. The reaction mixture is maintained at 0°-4° C. for 15 minutes. 3-Methyl-o-phenylenediamine (10 g.) is then added to the reaction mixture, and the resulting product is kept at room temperature for a few hours and then heated on a steam-bath for about 2.5 hours. After cooling to room temperature, the mixture is evaporated under reduced pressure, poured into 200 ml. water, and rubbed until solid. The product is removed by suction-filtration, dissolved in 5% aqueous sodium hydroxide solution, and clarified by gravity filtration. The benzimidazole derivative is precipitated by the addition of the alkaline solution to a slight excess of dilute acetic acid.

Provenance & Evidence