Sodium Hydroxide → 1-Amino-2-nitro-4-methoxyethylthiobenzene

HRID 596586Notes

Reaction equation

HRID 596586 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][CH2:13][O:14][CH3:15])=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17])(=O)C.[OH-].[Na+]>CO>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][CH2:13][O:14][CH3:15])=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 540479021-Acetamido-2-nitro-4-methoxyethylthiobenzene

Product 1

HCID 539497771-Amino-2-nitro-4-methoxyethylthiobenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.4 G. of 1-acetamido-2-nitro-4-methoxyethylthiobenzene is treated with 3 ml. 5N sodium hydroxide and 6 ml. methanol in the steam bath for about 15 minutes. The mixture is stripped under vacuum and the residue extracted with chloroform. The dried extracts are evaporated giving 1-amino-2-nitro-4-methoxyethylthiobenzene as a red crystalline solid.

Workup

  1. extractionthe residue extracted with chloroform
  2. customThe dried extracts are evaporated

Sources & evidence

ORD record
ord-51ceb430a2114c90a8964a7725cdd469
Source dataset
uspto-grants-1977_03
Patent number
US04011320

Reaction notes

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