Dimethyl Sulfate → HCID 22452645, compound

HRID 596590Notes

Reaction equation

HRID 596590 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.[OH-].[Na+].[CH3:17]OS(OC)(=O)=O>>[CH3:17][O:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 21450344HCID 21450344, compound

Product 1

HCID 22452645HCID 22452645, compound

Procedure

A mixture of 0.02 mole of 3-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid, and 40 ml. of 2 N sodium hydroxide solution is treated with 0.04 mole of dimethylsulfate over a 5 minutes period, and the mixture is stirred for 24 hours. The mixture is washed with 3 × 50 ml. of ether and acidified with dilute hydrochloric acid. The precipitate is collected, washed with water, dried at room temperature and 100μ pressure and recrystallized from cyclohexane.

Workup

  1. washThe mixture is washed with 3 × 50 ml
  2. customThe precipitate is collected
  3. washwashed with water
  4. customdried at room temperature
  5. custom100μ pressure and recrystallized from cyclohexane

Sources & evidence

ORD record
ord-be87bbe540cf4fb5b9c31419c109741a
Source dataset
uspto-grants-1977_03
Patent number
US04011326

Reaction notes

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