Sodium hydride → HCID 21450346, compound

Participants

Reaction Steps

A solution of 5.0 mmoles of product from Step D in 5 ml. of dimethylformamide is treated with 5.0 mmoles of sodium hydride/mineral oil emulsion. After stirring 10 minutes 1.0 g. of propyl iodide is added. After stirring 2 hours, the mixture is concentrated in vacuo to remove the dimethylformamide. Water (10 ml.) is added to the residue and the solids are collected and recrystallized from cyclohexane to give 2-(4-propoxy-5,6,7,8-tetrahydronaphth-2-yl)oxazolo[4,5-b]pyridine.

Provenance & Evidence