Bromoacetic Acid → HCID 54489760, compound

Participants

Reaction Steps

A mixture of sodium hydride (0.22 g., 4.6 mM of 50%); N-(2-phenoxyethyl) 7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxamide (1.0 g., 2.2 mM); bromoacetic acid (0.319 g., 2.3 mM) and N,N-dimethylformamide (50 ml.) is refluxed for 6 hours and then cooled to room temperature. The precipitate which forms is separated by filtration and dried under vacuum to give 0.476 g. (43%) of product; m.p. 310°-315° C.

Provenance & Evidence