Styrene Oxide → N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethylamine

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 g. (0.102 mol) of 1-(3,4-dimethoxyphenyl)-2-aminopropane and 12.01 ml. (0.102 mol) of styrene oxide is heated and stirred at 100° C. under argon for 18 hours. The cooled reaction mixture is dissolved in a minimum amount of benzene and petroleum ether is then added to precipitate a solid which turned to a liquid upon standing. Fractional vacuum distillation yields N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethylamine, b.p. 205°-225° C./0.2 mm.

Provenance & Evidence