Tert-Butylamine → HCID 21450288, compound

Participants

Reaction Steps

A stirred mixture of 6-[3-chloro-4-(2,3-epoxypropoxy)-phenyl]-4,5-dihydro-3(2H)-pyridazinone (2.91g, 0.01 mole) methanol (58 ml), and t-butylamine (6.6ml, 0.06 mole) was heated under reflux for 90 minutes. Evaporation of the solution under reduced pressure gave a glassy solid, 3.79g. The hydrochloride (m.p. 229°-238° C decomposition) was recrystallised from ethanol-ether to give pure 6-[4-(3-t-butylamino-2-hydroxypropoxy)-3-chlorophenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride m.p. 234°-238° C (decomposition).

Provenance & Evidence