Sodium Carbonate → HCID 21450269, compound

HRID 596689Notes

Reaction equation

HRID 596689 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N:9]([CH2:13][CH2:14][OH:15])[CH2:10][CH2:11]O)[CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N:9]2[CH2:10][CH2:11][O:15][CH2:14][CH2:13]2)[CH:3]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 21450282HCID 21450282, compound

Product 1

HCID 21450269HCID 21450269, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
160 °C

Procedure

4-Bromo-2-bis(2-hydroxyethyl)aminophenol (2.5g) was dissolved in 70% sulphuric acid (25 ml) and the solution heated to 160° C for three hours, allowed to cool, then neutralised with saturated sodium carbonate solution. Extraction with ether and evaporation of the extracts gave crude 4-bromo-2-morpholinophenol which was crystallised from ether gave the pure phenol (1.4g, 60%, m.p. 128° C).

Workup

  1. temperatureto cool
  2. extractionExtraction
  3. customwith ether and evaporation of the extracts

Sources & evidence

ORD record
ord-e3d5427788214918a7d5b43d4e7bf336
Source dataset
uspto-grants-1977_03
Patent number
US04011321

Reaction notes

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