反应详情

Zinc chloride (0.014 g) was added to a solution of methyl cis-(1aRS,7bSR)-5-methoxymethyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate (Intermediate 7, 0.53 g) and acetyl chloride (0.77 mL) in anhydrous diethyl ether (50 mL) and the resultant mixture was stirred for 1.5 hours. The mixture was washed with water, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give methyl cis-(1aRS,7bSR)-5-chloromethyl-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-4-carboxylate (0.486 g) as a gum.

1. washThe mixture was washed with water
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customThe filtrate was evaporated to dryness