反应详情

A solution of 10.0 g. p-tetradecyloxyphenylacetic acid in 100 ml. absolute benzene is treated with 19.9 g thionylchloride and refluxed for 2.5 hours. The reaction mixture is then evaporated under vacuum (i.v.) and azeotroped several times with benzene to remove residual thionylchloride, to obtain crude p-tetradecyloxyphenylacetylchloride, which may be used in Step E, below, without further refining.

1. temperaturerefluxed for 2.5 hours
2. customThe reaction mixture is then evaporated under vacuum (i.v.)
3. customazeotroped several times with benzene
4. customto remove residual thionylchloride