反应详情

A mixture of 5-cycloheptyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.05 mole), the dimethyl acetal of 2-methyl-aminoacetaldehyde (0.1 mole) and benzene (60 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and reflux condenser. The reaction mixture is heated at reflux for a period of about 15 minutes. After this time the mixture is stripped of benzene under reduced pressure to yield a solid product as the residue. The residue is then recrystallized to yield the desired product the dimethyl acetal of 2-[1-methyl-3-(5-cycloheptyl-1,3,4-thiadiazol-2-yl)-ureido] acetaldehyde.

1. customequipped with a mechanical stirrer
2. temperaturereflux condenser
3. temperatureThe reaction mixture is heated
4. temperatureat reflux for a period of about 15 minutes
5. customto yield a solid product as the residue
6. customThe residue is then recrystallized