HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Propenenitrile, 3-(4-fluorophenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Formate | HCID 2723810 | — |
| Reactant | 3-(4-Fluorophenyl)-2-propenal | HCID 53384379 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 2-Propenenitrile, 3-(4-fluorophenyl)- | HCID 367324 | 70.4% |
Reaction Steps
p-Fluorocinnamaldehyde (9.0 g.) was refluxed for 1 hr. in 98% formic acid containing sodium formate (10 g.) and hydroxylamine hydrochloride (7 g.). The solution was cooled and poured into water (275 ml.), giving a solid. This was washed well with water, leaving p-fluorocinnamonitrile (6.21 g., 70%), m.p. 64°-65°, λmax. (EtOH) 271 nm ε 22500.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012377 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-e9949bbebf3b423f8e3963e521514c62 |
| Source note | uspto-grants-1977_03 |