Acetic Acid → HCID 22796377, compound

Participants

Reaction Steps

to a solution of N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amide hydrate in 11.6 parts by volume glacial acetic acid and 0.12 part by volume 2-mercaptoethanol is added 5.8 parts by volume of a 6.04 M solution of hydrochloric acid in dioxane. After stirring for approximately five minutes, the solvent is removed under reduced pressure. The residue is triturated with ethyl ether, filtered and vacuum-dried to afford L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amide hydrochloride. This compound is represented by the following formula.

Provenance & Evidence