HRID596807

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(N)=O

HCID22796331

未命名化合物

结构：CSCC[C@H](N)C(=O)N[C@@H](CC(=O)O)C(=O)CC(C)(N)C(N)=O.Cl

HCID131710666

未命名化合物

PRODUCTS

生成物

结构：CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)CC(C)(N)C(N)=O

HCID131710665

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

When an equivalent quantity of L-methionyl-L-aspartyl-2-amino-2-methylpropionamide hydrochloride is substituted for the L-methionyl-L-aspartyl-D-alanine amide hydrochloride of Example 6, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-2-amino-2-methylpropionamide containing 1/3 mole of water of hydration per mole. This compound is represented by the following formula. ##STR15##Elemental analysis of this compound shows C: 54.45%; H: 6.69%; N: 12.69% and S: 4.96%. Theory is C: 54.36%; H: 6.71%; N: 13.11% and S: 5.00%.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf8b7d2b172a4c23b3ee148aaba75f04
来源数据集: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04012367
来源说明: uspto-grants-1977_03

反应 SMILES

Cl.[NH2:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([CH2:18][C:19]([NH2:24])([CH3:23])[C:20]([NH2:22])=[O:21])=[O:17])[CH2:12][C:13](=[O:15])[OH:14])=[O:9])[CH2:4][CH2:5][S:6][CH3:7].[C:25]([O:29][C:30]([NH:32][C@H:33]([C:44](N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)C)=O)CC(=O)O)=O)CCSC)=[O:45])[CH2:34][C:35]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[NH:37][CH:36]=1)=[O:31])([CH3:28])([CH3:27])[CH3:26]>O>[C:25]([O:29][C:30]([NH:32][C@H:33]([C:44]([NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([CH2:18][C:19]([NH2:24])([CH3:23])[C:20]([NH2:22])=[O:21])=[O:17])[CH2:12][C:13](=[O:14])[OH:15])=[O:9])[CH2:4][CH2:5][S:6][CH3:7])=[O:45])[CH2:34][C:35]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[NH:37][CH:36]=1)=[O:31])([CH3:27])([CH3:28])[CH3:26]