HRID596812

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(N)=O

HCID22796331

未命名化合物

结构：CCCNC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCSC.Cl

HCID22796356

未命名化合物

PRODUCTS

生成物

结构：CCCNC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C

HCID22796332

未命名化合物

PROCEDURE

实验过程

When an equivalent quantity of L-methionyl-L-aspartyl-D-alanine n-propylamide hydrochloride is substituted for the L-methionyl-L-aspartyl-D-alanine amide hydrochloride of Example 6, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine n-propylamide. This compound melts at about 143.5°-148° C. with decomposition and is represented by the following formula.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7c2617dbcc114a10ab5bb5e45f67f47f
来源数据集: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04012367
来源说明: uspto-grants-1977_03

反应 SMILES

Cl.[CH2:2]([NH:5][C:6](=[O:26])[C@@H:7]([CH3:25])[NH:8][C:9](=[O:24])[C@H:10]([CH2:20][C:21](=[O:23])[OH:22])[NH:11][C:12](=[O:19])[C@H:13]([CH2:15][CH2:16][S:17][CH3:18])[NH2:14])[CH2:3][CH3:4].[C:27]([O:31][C:32]([NH:34][C@H:35]([C:46](N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)C)=O)CC(=O)O)=O)CCSC)=[O:47])[CH2:36][C:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[NH:39][CH:38]=1)=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[CH2:2]([NH:5][C:6](=[O:26])[C@@H:7]([CH3:25])[NH:8][C:9](=[O:24])[C@H:10]([CH2:20][C:21](=[O:22])[OH:23])[NH:11][C:12](=[O:19])[C@H:13]([CH2:15][CH2:16][S:17][CH3:18])[NH:14][C:46](=[O:47])[C@H:35]([CH2:36][C:37]1[C:45]2[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=2)[NH:39][CH:38]=1)[NH:34][C:32]([O:31][C:27]([CH3:30])([CH3:28])[CH3:29])=[O:33])[CH2:3][CH3:4]