Acetic Acid → HCID 70635149, compound

Participants

Reaction Steps

Benzhydryl 7-(2-thienylacetamido)-3-(2-iodoethoxycarbonyl)-2-cephem-4-carboxylate (2.79 g., 4.05 mmol.) was dissolved in a mixture of 8 ml. of glacial acetic acid and 48 ml. dimethylformamide at 0° and was reacted with 2.79 g. zinc dust (10.5 eq.) for 1.5 hours. The reaction mixture was diluted with ethyl acetate and filtered through a celite filter. The filtrate was washed successively with sodium bicarbonate solution (3X), water, 1N.HCl, and brine and then dried (Na2SO4). Evaporation to dryness in vacuo gave 1.92 (89%) of benzhydryl 7-(2-thienylacetamido)-3-carboxy-2-cephem-4-carboxylate: nmr (CDCl3) δ3.84 (s, side chain CH2), 4.99 (d, 1, J = 4.0 Hz, C6 --H), 5.45 (m, C4 --H and C7 --H) and 7.80 (s, C2 --H).

Provenance & Evidence