HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (3-Amino-6-chloro-2-pyridyl) (2-chlorophenyl) ketone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | HCID 20520014 | HCID 20520014 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3-Amino-6-chloro-2-pyridyl) (2-chlorophenyl) ketone | HCID 3016382 | — |
Reaction Steps
43 grams of 2-benzoyl-3-amino-6-chloropyridine were dissolved in 100 ml of dioxane, then 16 ml of pyridine and finally with stirring 18 ml of propionyl chloride were added. The mixture was stirred for 2 hours, then water was added until crystallization began. The material which precipitated was recrystallized from methanol/water. Yield 48 grams; M.P. 40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012397 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-f549e615f4dd4d298eddcf21aae54f60 |
| Source note | uspto-grants-1977_03 |