1-Diethylamino ethyl-2-phenyl-3-keto piperazine → 1-Benzyloxy benzyl-2-phenyl piperazine

HRID 596856Notes

Reaction equation

HRID 596856 reaction equation
[CH2:1]([O:8][C:9]1([CH:28]=[CH:27][CH:26]=[CH:25][CH2:24]1)[CH2:10][N:11]1[CH2:16][CH2:15][NH:14][C:13](=O)[CH:12]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)C(N1CCNC(=O)C1C1C=CC=CC=1)C)C>>[CH2:1]([O:8][C:9]1([CH:24]=[CH:25][CH:26]=[CH:27][CH2:28]1)[CH2:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 214485351-Diethylamino ethyl-2-phenyl-3-keto piperazineHCID 706374581-Benzyloxy benzyl-2-phenyl-3-keto piperazine2×

Product 1

HCID 681169561-Benzyloxy benzyl-2-phenyl piperazine

Procedure

1-Benzyloxy benzyl-2-phenyl-3-keto piperazine prepared according to Example 12, is reduced by following the procedure described hereinabove in Example 8 (a) whereby, in place of 1-diethylamino ethyl-3-keto-2-phenyl piperazine, the equimolecular amount of said 1-benzyloxy benzyl-2-phenyl-3-keto piperazine is used. The resulting 2-phenyl piperazine compound is obtained in the form of white crystals melting at 140-141° C.

Sources & evidence

ORD record
ord-173806e0eec14cf08110bbe5b78f51f5
Source dataset
uspto-grants-1977_03
Patent number
US04012389

Reaction notes

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