HCID 21448647, compound → HCID 21448648, compound

HRID 596875Notes

Reaction equation

HRID 596875 reaction equation
[ClH:1].[CH2:2]([CH:9]1[C:14]([CH3:16])([CH3:15])[C:13](=[O:17])[CH2:12][CH2:11][N:10]1[CH3:18])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO.[Pt]=O>[ClH:1].[CH2:2]([CH:9]1[C:14]([CH3:16])([CH3:15])[CH:13]([OH:17])[CH2:12][CH2:11][N:10]1[CH3:18])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 21448647HCID 21448647, compound

Product 1

HCID 21448648HCID 21448648, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A solution of 9 g of 2-benzyl-1,3,3-trimethyl-4-piperidone hydrochloride in 50 ml of methanol is submitted to catalytic hydrogenation at room temperature and atmospheric pressure, with 0.4 g platinum oxide as the catalyst. The product is crystallized from ethanol/ether. Yield 98%. Melting point, after recrystallization, 213°-222° C.

Workup

  1. customis submitted to catalytic hydrogenation at room temperature
  2. customThe product is crystallized from ethanol/ether
  3. customMelting point, after recrystallization, 213°-222° C.

Sources & evidence

ORD record
ord-e40f24b2688642d5b7b2d46246843db1
Source dataset
uspto-grants-1977_03
Patent number
US04012392

Reaction notes

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