Hydrochloric Acid → HCID 21448604, compound

Participants

Reaction Steps

In a manner similar to the method described in example 47, 5 g of 1-benzyl-3,3-dimethyl-2-(p-methoxybenzyl)-4-piperidone is reacted with acetylene lithium (prepared from 1 g of lithium in 75 ml of liquid ammonia). The crude product from this reaction is reduced catalytically as described before, leading to the above-mentioned compound which is secured as the hydrochloride. Yield 55%. Melting point 171° - 172° C with decomposition.

Provenance & Evidence