2,2-Diethoxyethylamine → HCID 178467944, compound

Participants

Reaction Steps

A solution of 98 g (0.33 mole) of ethyl 5-(4-nitrophenyl)-2-furimidate hydrochloride and 48 g (0.36 mole) of aminoacetaldehyde diethyl acetal in 1500 ml of absolute ethanol was heated under reflux for 4 hr. After standing in a refrigerator for 2 days, the solid which was deposited was collected by filtration and washed with anhydrous ether to give 38 g (30%) of N-(2,2-diethoxyethyl)-5-(4-nitrophenyl)-2-furamidine hydrochloride. The filtrate was concentrated on a rotary evaporator. The solid which was deposited was collected by filtration and washed with anhydrous ether to give 34 g (57% total yield) of additional product, m.p. 220°-280° (dec.)

Provenance & Evidence