Aminoacetaldehyde dimethyl acetal → HCID 21449089, compound

Participants

Reaction Steps

To a stirring mixture of 110 g (0.36 mole) of ethyl 5-(3-trifluoromethylphenyl)-2-furimidate hydrochloride and 1700 ml of absolute ethanol was added 38 g (0.36 mole) of aminoacetaldehyde dimethyl acetal with dissolution. The reaction solution was refluxed for 6 hours, the solvent was removed on the Calab evaporator, and the residual solid was washed in hexane and air dried to yield 106 g (78%) of N'-(2,2-dimethoxyethyl)-5-(3-trifluoromethylphenyl)-2-furamidine hydrochloride. A sample was recrystallized from acetonitrile and dried at room temperature to give a m.p. of 173°-174°.

Provenance & Evidence