HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 1-Benzoyl-2-(methylsulfanyl)-1,2-dihydro-3H-indol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-{2-[(Methanesulfinyl)acetyl]phenyl}benzamide | HCID 21414519 | — |
| Product | 1-Benzoyl-2-(methylsulfanyl)-1,2-dihydro-3H-indol-3-one | HCID 21414522 | 68.4% |
Reaction Steps
2'-[(methylsulfinyl)-acetyl]benzanilide (7 g) is refluxed in benzene containing 1 equivalent of trifluoroacetic acid for 1 hour. The solvents are removed under reduced pressure to give an oil which crystallizes on standing. Recrystallization from ethyl acetate gives 1-benzoyl-2-(methylthio)-3-indolinone (4.5 g 67%) m.p. 126°-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012422 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-1e471593b6b94fbea263196c39aad99c |
| Source note | uspto-grants-1977_03 |