Thionyl Chloride → HCID 46880047, compound

Participants

Reaction Steps

In another procedure on the same scale, the thionyl chloride in 25 ml of EDC was stirred at 65° while a warm solution of 4-hydroxy-2-butynyl N-(3-chlorophenyl)carbamate in 75 ml of EDC was added dropwise over a period of 60 minutes. After 17 hours at 65°, the solvent was evaporated to afford 6.5 g of barban which was analyzed by HPLC: barban -- 97.5% (w/w), biscarbamate -- 1.0% (w/w); bisurea -- 1.6% (w/w).

Provenance & Evidence