Dimethylformamide → HCID 46880047, compound

Participants

Reaction Steps

To a warm (50°) stirred solution of 4-hydroxy-2-butynyl N-(3-chlorophenyl)carbamate (59.9 g., 0.500 mole) and dimethylformamide (0.6 g) in 150 ml of EDC was added 250 ml of 12.5% phosgene in benzene over a period of about 30 minutes. The reaction mixture was heated at 50° for 4.5 more hours, then at 60° for 2 hours. Evaporation of solvent afforded a quantitative yield of technical barban.

Provenance & Evidence