Ammonium Hydroxide → HCID 12814733, compound

Participants

Reaction Steps

A solution of the above hydrochloride (0.6 g) in methanol (10 ml) and ammonium hydroxide (d.0.880; 10 ml) was allowed to stand at room temperature for 48 hours. On evaporation, a residue was obtained which was neutralised with sodium bicarbonate solution and extracted with ethyl acetate. When dried and evaporated, the solution gave the amide as a white solid, m.p. 154° (63% yield).

Provenance & Evidence