反应详情

To a stirred solution of 7.2 g of 3-methylindole-1-ethanol, described in Example 1, in 500 ml. of dry ether (ice bath) is slowly added 1.2 ml of phosphorus tribromide in 100 ml of dry ether. A dark red oily complex separates. The reaction mixture is stirred 36-48 hours at room temperature, then decomposed with ice and water. The separated ether-layer is quickly washed with a 10% solution of sodium bicarbonate and with water again, dried over calcium chloride for 2 min., decanted, and dried over magnesium sulfate for 30 min. The filtrate is evaporated yielding 1-(2-bromoethyl)-3-methylindole.

1. washThe separated ether-layer is quickly washed with a 10% solution of sodium bicarbonate and with water again
2. dry with materialdried over calcium chloride for 2 min.
3. customdecanted
4. dry with materialdried over magnesium sulfate for 30 min
5. customThe filtrate is evaporated