3-Methylindole-1-ethanol → beta-Isopropyl-alpha,3,7-trimethyl-indole-1-ethanethiol
Reaction equation
N1(CC[SH:12])C2C(=CC=CC=2)C=C1.N1(CCO)C2C(=CC=CC=2)C=C1.CC1C2C(=CC=CC=2)N(CCO)C=1.[CH:38]([CH:41]([N:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][C:52]=2[CH3:54])[C:47]([CH3:55])=[CH:46]1)[CH:42]([CH3:44])O)([CH3:40])[CH3:39]>>[CH:38]([CH:41]([N:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][C:52]=2[CH3:54])[C:47]([CH3:55])=[CH:46]1)[CH:42]([CH3:44])[SH:12])([CH3:40])[CH3:39]Participants
5
Procedure
By following procedure A or B of Example 2 other indole-1-ethanethiol intermediates of formula III, for example those described in Examples 57 to 106 may be prepared by the appropriate choice of indole-1-ethanol intermediates of formula III. For example, by replacing 3-methylindole-1-ethanol with an equivalent amount of β-isopropyl-α,3,7-trimethylindole-1-ethanol, β-isopropyl-α,3,7-trimethyl-indole-1-ethanethiol is obtained. Likewise, by replacing 3-methylindole-1-ethanol with an equivalent amount of 3-isopropylindole-1-ethanol, 3-isopropylindole-1-ethanethiol is obtained.
Sources & evidence
- ORD record
- ord-754644f4deab4dc0bfb8ed69712ac911
- Source dataset
- uspto-grants-1977_03
- Patent number
- US04012511
Reaction notes
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