HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxysuccinimide → (S)-2,5-dioxopyrrolidin-1-yl 2-methyl-5-phenylpentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (S)-2-methyl-5-phenylpentanoic acid | HCID 90054467 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2,5-dioxopyrrolidin-1-yl 2-methyl-5-phenylpentanoate | HCID 90054468 | — |
Reaction Steps
To a mixture consisting of (S)-2-methyl-5-phenylpentanoic acid (20mb(i), 290 mg, 1.51 mmol) in dichloromethane (20 mL) was added N-hydroxysuccinimide (191 mg, 1.66 mmol), 4-dimethylaminopyridine (203 mg, 1.66 mmol) and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (318 mg, 1.66 mmol). The resulting reaction mixture was stirred for two hours at room temperature. The reaction mixture comprising 18mb(i) was carried on directly to the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440919B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-73686f896e594a13acd095a2757ab4c9 |
| Source note | uspto-grants-2016_09 |