HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1-Hydroxy-2-ethyl-6,7-dichloro-5-indanyloxy)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetic acid, 6,7-dichloro-2-ethyl-1-oxo-5-indanyloxy- | HCID 33794 | — |
| Reactant | Potassium borohydride | HCID 4192641 | — |
| Solvent | Water | HCID 962 | — |
| Product | (1-Hydroxy-2-ethyl-6,7-dichloro-5-indanyloxy)-acetic acid | HCID 21449485 | — |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
A stirred suspension of (1-oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetic acid (12.12 g., 0.04 mole) in water (400 ml.) is cooled to 5° C. and treated during a one hour period with solution of potassium borohydride (4.0 g., 0.075 mole) in water (200 ml.). The reaction is stirred for 1 hour then acidified with hydrochloric acid affording 10.6 g. (87%) of (1-hydroxy-2-ethyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 121°-122° C. after recrystallization from benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012524 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-0b7634c582df427e9a27dc0fdb7718d7 |
| Source note | uspto-grants-1977_03 |